DAVID Cameron has ordered the Met Police to reopen every file on missing Madeleine McCann for a full review of all evidence gathered on her.
The PM acted after the abducted youngster's parents wrote to him in an emotional open letter, published in The Sun yesterday.
Clearly touched by the couple's plea for help, the Prime Minister held urgent talks on the issue with Home Secretary Theresa May.
And last night it emerged that he has ordered the Met Police to reopen all the files on Madeleine for a full review of ALL evidence ever gathered.
If the probe reveals any fresh leads over how the little girl disappeared from a Portuguese holiday apartment four years ago, a full-blown police investigation will begin.
Living in hope ... Maddie's mum Kate McCann in central London
A small team of detectives — drawn from the Met's specialist crime directorate — will be dispatched to Portugal as soon as possible, police sources said last night.
Kate, 43, and 42-year-old Gerry had appealed to the PM in a poignant open letter, urging him to re-launch the search for Madeleine and press for a full independent and transparent review into her case.
He said in his reply: "Thank you for your heartfelt and moving letter. Your ordeal is every parent's worst nightmare and my heart goes out to you both.
"I simply cannot imagine the pain you must have experienced over these four agonising years, and the strength and determination you have shown throughout is remarkable. I have asked the Home Secretary to look into what more the Government could do to help find Madeleine.
"She will be writing to you today, setting out new action involving the Metropolitan Police Service which we hope will help boost efforts in the search for Madeleine."
Appeal... Kate and Gerry McCann with Lorraine Kelly, holding The Sun
Rex Telling them he sincerely hoped his action would give their hunt "the new momentum that it needs", the PM also promised to stay "in close touch" with the couple throughout.
He added: "I know that everyone hopes and prays for a successful outcome, and our thoughts remain with you and your family."
Kate, whose book on her daughter — titled simply Madeleine — has been serialised all week in The Sun, admitted this week that the couple's own efforts to trace the missing girl "don't seem to be working".
She and heart consultant Gerry appeared on Sun columnist Lorraine Kelly's ITV1 show yesterday morning, where Gerry said: "We want people to read the book because it puts what's happened to us and what we are doing in context. But more than anything, we want the public to get behind the search for Madeleine like they did in 2007."
We can reveal Home Office officials have been secretly working on re-opening the hunt for Maddie for nine months.
After that, the Home Secretary quietly ordered her officials to liaise with international law enforcement agencies and do what they could in the hope of sparking a new development in the case.
Mrs May told The Sun last night: "We all want to see this beautiful little girl returned to her parents. That's why we have been doing everything we can behind the scenes."
The only British police involvement in Madeleine's case prior to last night's announcement was carried out on behalf of the Portuguese cops.
Leicestershire Police, the McCanns' local force, were the "liaison force" responsible for collating all investigation work by officers across the UK.
Search ... Maddie McCann
All the information was then sent on to Portuguese police. There was never a British investigation into Madeleine's disappearance as her abduction happened in Portugal.
The case review last night won cross-party backing in Westminster.
Shadow Home Secretary Yvonne Cooper said: "We fully back the McCanns' request for information in Madeleine's case to be reviewed.
"Any overlooked piece of this jigsaw could be important. A British child is missing, and the British authorities should do everything in their power to help in the search."
Madeleine's parents have been campaigning for a review for several years. They feel it is "crucial" to finding their daughter, fearing vital leads, sightings and other clues are buried away in Portuguese police files.
They are desperately hoping that a fresh look at the files, similar to a criminal "cold case" review, may discover something that was overlooked in the original investigation.
Video: PM reopens Maddie files
DAVID Cameron orders full review of missing Madeleine McCann caseAll the files relating to Madeleine's case are held by the Portuguese Judiciary in Portimao — including witness statements and details of sightings.
More than 30,000 pages were released after the Portuguese investigation was shelved in 2008, but some were held back, with police insisting they could not be made public.
Last night Kate and Gerry told The Sun: "We welcome the Government's response. This is clearly a step in the right direction.
"The expertise of the Metropolitan Police is renowned and we are reassured by our government's commitment to the search for Madeleine.
"We would like to thank Mr Cameron and the Home Secretary for committing such a significant resource as the Metropolitan Police to begin the review process. We would also specifically like to thank The Sun, News International, and the general public for supporting the campaign to find Madeleine in the way they have."
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